Healing of Diabetic Foot Ulcers in Patients Treated at the Copenhagen Wound Healing Center in 1999/2000 and in 2011/2012
Table 1
Risk factors affecting healing time in chronic diabetic foot ulcers.
Risk factors and average ulcer duration
1999/2000
(324)
value1
value2
2011/2012
(327)
value3
value4
Median (range), months
+
-
+
-
Peripheral arterial insufficiency
6.0 (60)
5.3 (53.8)
0.2
0.5
6.0 (60)
7.8 (30.5)
0.4
0.1
Ischemic heart disease
8 (35)
5.9 (61.3)
0.4
0.6
6.9 (55)
6.6 (67.8)
0.7
0.2
Neuropathy
5.9 (61.3)
6.4 (24.5)
0.9
0.3
6.5 (67.8)
5.3 (10.5)
0.3
0.8
Chronic nephropathy
10.4 (50.5)
7.5 (61.3)
0.4
0.3
4.3 (40.3)
7.0 (67)
0.6
1.0
Retinopathy
9.0 (51.8)
5.5 (24.3)
0.2
0.9
7.3 (54.8)
5.6 (25.0)
0.2
0.8
Metformin
6.5 (57)
7.3 (61.3)
0.3
0.7
6.0 (67.8)
6.8 (43.8)
0.6
0.9
Basal insulin
6.8 (61.3)
7.0 (57.0)
0.9
0.4
7.1 (66.5)
6.3 (56)
0.5
0.8
Bolus insulin
7.1 (54)
7.0 (61.0)
0.9
0.8
6.6 (40.3)
6.5 (67.8)
0.9
0.9
Infection
9.0 (61.0)
3.5 (17.5)
<0.001
0.4
7.4 (67.8)
5.1 (4.3)
0.4
0.3
Distal pulse, right ADP
6.0 (61.0)
7.8 (60)
0.07
0.03
7.0 (67.0)
7.4 (56)
0.8
0.9
Former ulcer(s)
6.0 (61.3)
7.0 (57.0)
0.9
0.08
8.1 (55.8)
6.3 (67.8)
0.1
0.9
Smoking
7.3 (60.8)
5.4 (60)
0.03
0.4
6.8 (42.8)
6.5 (56)
0.8
0.07
Type 2 DM
5.8 (61.3)
7.9 (53.8)
0.3
0.08
6.7 (67.8)
5.5 (22.5)
0.8
0.9
Male gender
6.8 (61.3)
5.1 (26.8)
0.3
0.3
7.0 (67.5)
5.3 (56.0)
0.4
0.5
Antibiotics
6.6 (61.3)
5.6 (16.5)
0.5
0.4
7.3 (67.8)
4.8 (40.3)
0.3
0.9
Toe location of ulcer
4.9 (42.8)
9 (61)
0.001
0.007
7.0 (67.0)
8.5 (55.3)
0.5
0.7
Heel location
8.0 (59.5)
6.8 (61.3)
0.2
0.5
8.3 (55.3)
7.9 (67.0)
1.0
0.06
Plantar location
8.7 (61)
5.4 (60)
0.03
0.6
10 (46.0)
7.3 (67.0)
0.07
0.07
Dorsal location
9.7 (33.3)
6.8 (61.3)
0.4
0.3
5.8 (16.0)
8.0 (67.0)
0.1
0.05
The table shows the median and the range. The calculation is based on the first ulcer each patient had at the time of first contact with CWHC ().. Compared to type 1 DM. 1 value comparing “+” and “-” in 1999/2000. 2Comparing “+” in years 1999/2000 and 2011/2012. 3Comparing “+” and “-” in 2011/2012. 4Comparing “-” in years 1999/2000 and 2011/2012. 5Total number of ulcers with known duration. Parenthesis: the total number of patients with DFUs in 1999/2000 or 2011/2012. 6 is the number of ulcers with known duration.
