Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease
Table 2
Summary of univariate and multivariate regression analyses predicting urinary CN-1 concentrations in T2DM and nondiabetic CKD patients ().
Univariate analysis
Multivariate analysis
Variable
Coefficient ()
95% CI
value
Coefficient ()
95% CI
value
Age (years)
-0.007
-0.014
0.001
0.092
0.002
-0.005
0.010
0.56
Male sex
0.17
-0.08
0.42
0.18
0.14
-0.044
0.33
0.13
Nondiabetic kidney disease
0.075
-0.208
0.36
0.60
—
—
—
On renal replacement therapy
-0.095
-0.34
0.15
0.43
—
—
—
CNDP1 (CTG)5 homozygosity
-0.500
-0.43
0.08
0.17
-0.033
-0.23
0.16
0.74
Log (serum CN-1)
0.195
-0.012
0.40
0.065
0.21
0.053
0.36
0.009
Log (ACR)
0.47
0.37
0.57
<0.0001
0.48
0.37
0.60
<0.0001
eGFR (ml/min/1.73 m2)
-0.009
-0.009
-0.0004
0.032
0.001
-0.003
0.005
0.66
Univariate and multivariate regression models with log-transformed urinary CN-1 as the dependent variable. Goodness of fit of the multivariate regression full model: adjusted ;.
