Apolipoproteins A and B and PCSK9: Nontraditional Cardiovascular Risk Factors in Chronic Kidney Disease and in End-Stage Renal Disease

Figure 2

The biological functions of ApoA-I. In the liver, ApoA-I initiates the biogenesis of HDL and the lipid uptake and promotes cholesterol efflux. In the vascular endothelium, it maintains endothelial cell homeostasis. ApoE: apolipoprotein E; ABCA1: ATP-binding cassette transporters; LCAT: lecithin-cholesterol acyltransferase; SR-BI: scavenger receptor class B type I.