Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways
Islet transplantation treatment improved pathological lesions in diabetic rat testes. Representative images of testicular histological examination in each group ( for each group) (HE staining: ×200). . (a) Testicular slices of the control group showed normal spermatogonia (sg), spermatocytes (sp), seminiferous tubules (st), and sperm cells (spc). (b) Testicular slices of the DM group showed spermatogonial cells, spermatocytes, and sperm cells that were degenerated and vacuolated, as well as severely reduced germ cells. (c, d) Testicular slices of the IT group demonstrated more significant recovery of testicular structures compared with that of the INS group. DM: diabetes mellitus; INS: insulin treatment; IT: islet transplantation.
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