Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways

Figure 3

Islet transplantation treatment alleviated sperm count, MDA level, and SOD activity in the testicular tissue of diabetic rats. (a) The number of sperm in the DM group significantly decreased compared with that in the control group. The IT group showed more significant recovery of sperm cells compared with that in the INS group ( for each group). (b) MDA contents in the DM group increased more extensively than that in the control group. Compared with that of the INS group, the MDA concentration of the IT group decreased more significantly ( for each group). (c)The SOD activity in the DM group was significantly lower than that in other groups, and the IT group maintained significantly higher levels of SOD activity compared with that of the INS group ( for each group). DM: diabetes mellitus; INS: insulin treatment; IT: islet transplantation. vs. control; ^& vs. DM; ⁺ vs. INS.

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