Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais
Table 4
Odds ratios (ORs) and 95% confidence intervals (CIs) for 2-year progression of type 2 diabetes according to interaction between baseline serum CRP, IL-6, and TNF-α levels.
Variables
Univariate analysis
Multivariate analysis
Crude OR (95% CI)
value
Adjusted OR (95% CI)
value
Interaction of CRPa and IL-6b
CRP (low)+IL-6 (low)
1
1
CRP (low)+IL-6 (high)
2.28 (0.62-8.45)
0.218
1.78 (0.45-7.00)
0.412
CRP (high)+IL-6 (low)
2.65 (0.67-10.47)
0.164
2.01 (0.48-8.49)
0.340
CRP (high)+IL-6 (high)
5.96 (1.55-22.88)
0.009
5.11 (1.27-20.49)
0.021
Interaction of CRP and TNF-αc
CRP (low)+TNF-α (low)
1
1
CRP (low)+TNF-α (high)
1.61 (0.49-5.26)
0.429
1.51 (0.44-5.16)
0.509
CRP (high)+TNF-α (low)
1.23 (0.34-4.47)
0.756
1.17 (0.31-4.46)
0.822
CRP (high)+TNF-α (high)
4.05 (1.18-13.85)
0.026
4.11 (1.10-15.33)
0.035
Interaction of IL-6 and TNF-α
IL-6 (low)+TNF-α (low)
1
1
IL-6 (low)+TNF-α (high)
1.37 (0.55-3.40)
0.504
1.28 (0.50-3.32)
0.607
IL-6 (high)+TNF-α (low)
2.05 (0.44-9.47)
0.359
1.65 (0.33-8.42)
0.544
IL-6 (high)+TNF-α (high)
1.99 (0.71-5.58)
0.190
2.34 (0.79-6.97)
0.127
Interaction of CRP, IL-6 and TNF-α
CRP (low)+IL-6 (low)+TNF-α (low)
1
1
CRP (high)+IL-6 (high)+TNF-α (high)
5.71 (1.07-30.63)
0.042
4.77 (0.84-27.11)
0.078
Abbreviations: CRP: C-reactive protein; IL-6: interleukin 6; TNF-α: tumor necrosis factor alpha. OR was adjusted for age, gender, WHR, VF, and TG. aCRP (low): ; CRP (high): .bIL-6 (low): serum IL-6 in 1st tertile (<5.93 pg/ml); IL-6 (high): serum IL-6 in 3rd tertile (>85.65 pg/ml). cTNF-α (low): serum TNF-α in 1st tertile (<36.47 pg/ml); TNF-α (high): serum TNF-α in 3rd tertile (>73.30 pg/ml).
