Research Article
Baseline Triglyceride Level Affected the Efficacy of Vildagliptin in Treating Type 2 Diabetes: A Post Hoc Analysis of the VISION Study
Table 1
Patients’ baseline demographics and clinical characteristics (FAS) according to the 3 TG-based tertiles.
| | Vildagliptin+metformin (VLDM) | Metformin (HDM) | 1st tertile
| 2nd tertile
| 3rd tertile
| value | 1st tertile
| 2nd tertile
| 3rd tertile
| value |
| | Age (years) | 58 (11) | 57 (11) | 55 (11) | <0.0001 | 58 (10) | 56 (12) | 55 (11) | 0.0555 | | Male, (%) | 462 (55.9) | 419 (49.0) | 479 (58.5) | <0.0001 | 79 (45.9) | 73 (46.8) | 87 (56.1) | 0.1314 | | Weight (kg) | 67.2 (11.1) | 68.9 (10.8) | 71.7 (11.4) | <0.0001 | 66.4 (10.4) | 68.7 (11.4) | 71.2 (12.2) | 0.0007 | | BMI (kg/m2) | 24.4 (3.1) | 25.1 (7.9) | 25.7 (3.1) | <0.0001 | 24.6 (3.0) | 25.1 (3.4) | 25.6 (3.3) | 0.0119 | | Duration of DM (years) | 4.6 (4.5) | 4.1 (4.2) | 4.1 (3.9) | 0.0369 | 4.0 (4.3) | 3.8 (4.1) | 4.4 (4.4) | 0.4291 | | HbA1c (%) | 7.2 (0.9) | 7.2 (0.9) | 7.3 (0.9) | 0.0358 | 7.2 (0.8) | 7.2 (0.8) | 7.3 (0.8) | 0.5528 | | FPG (mmol/L) | 7.4 (1.9) | 7.5 (1.7) | 8.0 (2.0) | <0.0001 | 7.3 (1.7) | 7.5 (1.6) | 7.8 (1.9) | 0.0225 | | 120 min PPG (mmol/L) | 11.8 (3.6) | 12.6 (3.3) | 13.3 (3.8) | 0.013 | 11.0 (3.5) | 12.8 (3.5) | 11.6 (3.8) | 0.1754 | | TG (mmol/L) | 0.95 (0.23) | 1.63 (0.21) | 3.44 (2.11) | <0.0001 | 0.97 (0.21) | 1.62 (0.22) | 3.36 (2.12) | <0.0001 | | Total cholesterol (mmol/L) | 4.37 (0.87) | 4.78 (0.83) | 5.04 (0.93) | <0.0001 | 4.42 (0.90) | 4.88 (0.89) | 5.03 (0.98) | <0.0001 | | SBP (mmHg) | 125 (11) | 126 (11) | 126 (11) | 0.1743 | 125 (12) | 126 (12) | 127 (12) | 0.4498 | | DBP (mmHg) | 77 (8) | 77 (7) | 78 (8) | 0.0030 | 77 (7) | 77 (8) | 79 (7) | 0.0366 | | ALT (U/L) | 22 (13) | 26 (14) | 29 (15) | <0.0001 | 21 (10) | 25 (13) | 28 (14) | <0.0001 | | Plasma creatinine (μmol/L) | 64 (15) | 65 (16) | 66 (15) | 0.0286 | 64 (16) | 64 (15) | 66 (17) | 0.4972 |
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All data except for the gender were in mean (standard deviation (SD)). FAS: full analysis set; VLDM: vildagliptin (50 mg bid) plus metformin (500 mg bid); HDM: metformin uptitration (1000 mg bid); 1 st tertile: mmol/L; 2 nd tertile: ; 3 rd tertile: ; TG: triglyceride; BMI: body mass index; FPG: fasting plasma glucose; 120 min PPG: 120-minute postprandial blood glucose; SBP: systolic blood pressure; DBP: diastolic blood pressure; ALT: alanine aminotransferase. |
