Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Table 5

Associations between the SNPs and eGFR (mL/min/1.73 m²) in the study subjects.

Group	SNP	Major/minor allele	AA^†	Aa^†	aa^†	Additive model		Dominant model		Recessive model
						(SE)^‡	value	(SE)	value	(SE)	value
DKD group	rs2071699	C/T	109.6 (82.3, 136.3)	106.0 (81.3, 134.0)	120.6 (86.5, 144.5)	-0.006 (0.014)	0.6515	-0.001 (0.018)	0.9337	-0.032 (0.035)	0.3517
	rs499765	G/C	105.6 (70.8, 134.7)	112.0 (85.8, 137.4)	109.9 (81.3, 135.2)	-0.022 (0.012)	0.0820	-0.044 (0.019)	0.0182	-0.007 (0.023)	0.7539
	rs838136	A/G	106.5 (81.5, 138.6)	109.1 (81.5, 133.1)	113.1 (89.4, 144.5)	-0.018 (0.013)	0.1758	-0.016 (0.019)	0.3937	-0.035 (0.024)	0.1534
Non-DKD group	rs2071699	C/T	120.3 (101.5, 141.5)	119.3 (102.9, 138.9)	122.5 (109.5, 147.6)	-0.006 (0.007)	0.3575	-0.009 (0.009)	0.3047	-0.004 (0.016)	0.7964
	rs499765	G/C	117.5 (102.1, 136.9)	123.4 (103.5, 148.0)	116.8 (103.5, 135.6)	-0.010 (0.006)	0.1159	-0.019 (0.009)	0.0411	-0.004 (0.012)	0.7560
	rs838136	A/G	121.7 (104.3, 146.4)	120.7 (102.2, 141.1)	114.9 (96.8, 136.6)	0.013 (0.006)	0.0295	0.014 (0.009)	0.1108	0.024 (0.012)	0.0385

Data are shown as geometric means (SE). values were adjusted for age, gender, BMI, duration of diabetes, systolic blood pressure, diastolic blood pressure, and HbA_1c. values < 0.05 are shown in bold. ^†AA = major allele homozygous; Aa = heterozygous; aa = minor allele homozygous. ^‡ (SE) was calculated for log₁₀eGFR and refers to major alleles. eGFR: estimated glomerular filtration rate.