Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Table 6

Associations between the SNPs and AER (mg/24 h) in the study subjects.

	SNP	Major/minor allele	AA^†	Aa^†	aa^†	(SE)^‡	value
DKD group	rs2071699	C/T	100.6 (48.3, 318.7)	82.2 (45.1, 283.4)	78.5 (37.1, 262.0)	0.030 (0.039)	0.4389
	rs499765	G/C	90.0 (52.4, 334.3)	89.1 (42.7, 289.0)	89.8 (44.6, 267.5)	0.030 (0.034)	0.3782
	rs838136	A/G	77.3 (43.0, 282.3)	103.2 (50.1, 292.6)	90.1 (46.1, 227.4)	-0.028 (0.035)	0.4327
Non-DKD group	rs2071699	C/T	9.5 (6.5, 14.7)	8.7 (6.0, 13.8)	9.4 (6.8, 13.6)	0.014 (0.014)	0.3311
	rs499765	G/C	9.7 (6.1, 14.1)	9.0 (6.4, 14.7)	8.5 (6.5, 14.1)	0.0006 (0.013)	0.9632
	rs838136	A/G	8.9 (6.2, 13.8)	8.8 (6.2, 14.9)	10.0 (6.9, 14.6)	-0.007 (0.013)	0.5667

Data are shown as geometric means (SE). values were adjusted for age, gender, BMI, duration of diabetes, systolic blood pressure, diastolic blood pressure, and HbA_1c. ^†AA = major allele homozygous; Aa = heterozygous; aa = minor allele homozygous. ^‡ (SE) was calculated for log₁₀eGFR and refers to major alleles. AER: 24-hour urinary albumin excretion rate.