A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Diabetic Mice

<div>Histopathological evaluation of insulitis and immunohistochemistry of Foxp3<sup>+</sup> cells in islets. (a) Representative insulitis formation visualized in hematoxylin and eosin-stained pancreas sections from 33-week-of-age (WOA) nonobese diabetic (NOD) mice subjected to the indicated treatments (25 weeks after the last drug treatment). (b) Percentage of islets with a given degree of infiltration at 33 WOA in NOD female mice subjected to the indicated treatments. (c) Representative Foxp3<sup>+</sup> cell accumulation in Foxp3-stained pancreatic islet sections from 25 WOA NOD mice subjected to the indicated treatments. DAPI (blue) stains for nuclei. Data were obtained from three independent experiments. Bars: 100 <i>μ</i>m.</div>

Journal of Diabetes Research

fig2

Figure 2

Figure 2: A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Diabetic Mice 

Figure 2 | A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Diabetic Mice 