Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow

Table 1

Coronary ion channels and their physiological role in the regulation of coronary vascular tone.

Ion channel	Membrane effect	Functions
Nav	Depolarization	Endothelial-dependent coronary vasodilation
Cl-	Depolarization	Endothelial-independent vasoconstriction
Cav	Depolarization	Coronary vasoconstriction; coronary autoregulation and control of coronary microvascular resistance
Kv	Hyperpolarization	Endothelial-dependent and -independent coronary vasodilation
KATP	Hyperpolarization	Coronary vasodilation and metabolic regulation of coronary blood flow
KCa	Hyperpolarization	Redox-sensitive channel, coronary dilatation in response to endothelial-derived hyperpolarizing factor (EDHF), lipoxygenase metabolites, and H2O2