Antidiabetic Potential of Marine Brown Algae—a Mini Review

Table 1

Summary of tested brown algae and possible active agents responsible for the antidiabetes properties.

Family	Species	Active agents	Antidiabetic action
Lessoniaceae	Eisenia bicyclis	Dioxinodehydroeckol,	α-glucosidase inhibitor [20]
		7-phloroeckol	PTP 1B inhibition; α-glucosidase inhibitor [20]
		Fucoxanthin	PTP 1B inhibition; Aldose reductase inhibition; Aldose reductase; inhibition [26]
	Ecklonia cava	Dieckol	α-glucosidase inhibitor [43]
		Fucodiphloroethol G	α-amylase inhibitor[43]
		6,6-Bieckol	PTP 1B inhibition[43]
		7-Phloroeckol	ACE inhibitor[43]
		2-phloroeckol	α-glucosidase inhibitor; α-glucosidase inhibitor[43]
		Phlorofucofuroeckol-A	α-glucosidase inhibitor [30]; PTP 1B inhibition [30]; Aldose reductase inhibition [38]; Aldose reductase inhibition [38]; α-glucosidase inhibitor; PTP 1B inhibition [30]; ACE inhibitor; AGEs inhibition [55]; Aldose reductase inhibition [42]
	Ecklonia stolonifera	Phloroglucinol	α-glucosidase inhibitor [29]
		Eckol	PTP 1B inhibition α-glucosidase inhibitor [29]
		Dieckol	α-amylase inhibitor; ACE inhibitor[43]
		Phlorofucofuroeckol A	PTP 1B inhibition; α-glucosidase inhibitor [29]; α-amylase inhibitor; PTP 1B inhibition; ACE inhibitor [43]
		Fucosterol	α-glucosidase inhibitor [29]; ACE inhibitor; AGEs inhibition; PTP 1B inhibition; Aldose reductase inhibition [39]
Ishigeaceae	Ishige okamurae	Diphlorethohydroxycarmalol	α-glucosidase inhibitor; α-amylase inhibitor [28]
Sargassaceae	Myagropsis myagroides	Eckol	α-glucosidase inhibitor; α-amylase inhibitor [29]
	Sargassum serratifolium	Sargahydroquinoic acid	ACE inhibitor PTP 1B inhibition PTP 1B inhibition [51]
Fucaceae	Ascophyllum nodosum	Methanol extract	α-glucosidase inhibitor [31]α-amylase inhibitor [31]
Laminariaceae	Saccharina japonica	Pheophorbide-A	Aldose reductase inhibition [41]
		Pheophytin-A	Aldose reductase; inhibition [41]
Alariaceae	Undaria pinnatifida	Fucoxanthin	Aldose reductase inhibition [26]
Dictyotaceae	Dictyopteris undulata	(24S)-7b-methoxy-stigmasta-5, 28-diene-3b, 24-diol	PTP 1B inhibition [52]
		(24S)-7a-methoxy-stigmasta-5, 28-diene-3b, 24-diol	PTP 1B inhibition [52]