The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study

Table 2

Adjusted odds ratios and 95% confidence intervals for risk of diabetes across different red blood cell distribution width (RDW) quartile groups in 16,971 Chinese adults.

Model	Baseline RDW quartile groups (%)				Each percent of RDW	p trend
	Q1	Q2	Q3	Q4
	≤12.2	12.3~12.6	12.7~13.1	≥13.2
Sample	4,574	3,616	4,197	4,584	—	—
Case	619	532	716	836	—	—
Model 1	1.00 (ref)	1.03	1.14	1.18	1.13	0.001
		(0.92, 1.16)	(1.02, 1.27)	(1.06, 1.31)	(1.05, 1.21)
Model 2	1.00 (ref)	0.97	1.08	1.17	1.13	0.001
		(0.86, 1.1)	(0.96, 1.2)	(1.05, 1.3)	(1.05, 1.22)
Model 3	1.00 (ref)	0.99	1.1	1.22	1.17	<0.001
		(0.88, 1.12)	(0.98, 1.24)	(1.09, 1.38)	(1.08, 1.27)
Model 4	1.00 (ref)	1.04	1.17	1.31	1.22	<0.001
		(0.91, 1.17)	(1.04, 1.32)	(1.16, 1.48)	(1.12, 1.33)
Model 5	1.00 (ref)	0.99	1.11	1.2	1.16	<0.001
		(0.87, 1.12)	(0.99, 1.25)	(1.06, 1.36)	(1.06, 1.26)

Note: model 1: adjusting for age (y) and sex. Model 2: adjusting variables in model 1 and further BMI (kg/m²), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mmol/L), triglyceride (mmol/L), low-density lipoprotein cholesterol (mmol/L), high-density lipoprotein cholesterol (mmol/L), eGFR (mL/min per 1.73 m²), alanine transferase (U/L), and aspartate transferase (U/L). Model 3: adjusting variables in model 2 and further hemoglobin (g/L), hematocrit (10⁹/L), red blood cell count (10¹²/L), and white blood cell count (10⁹/L). Model 4: adjusting variables in model 3 and further high-sensitivity C-reactive protein (mg/L). Model 5: adjusting variables in model 4 and further fasting blood glucose (mmol/L) and glycated hemoglobin A1c (%).