The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study

Table 3

The adjusted hazardous ratios and 95% confidence interval for the risk of diabetes across red blood cell distribution width (RDW) quartile groups: sensitivity analyses.

		Baseline RDW quartile groups (%)				Each percent of RDW	p trend
		Q1; ≤12.2	Q2; 12.3~12.6	Q3; 12.7~13.1	Q4; ≥13.2
Sensitivity-1	Sample	4,389	3,448	3,925	4,245	—	—
	Case	566	486	639	746	—	—
	Model	1.00 (ref)	1.04 (0.91, 1.18)	1.18 (1.05, 1.34)	1.32 (1.16, 1.5)	1.23 (1.13, 1.35)	<0.001
Sensitivity-2	Sample	3,574	2,768	3,128	3,383	—	—
	Case	439	349	483	539	—	—
	Model	1.00 (ref)	1.01 (0.87, 1.18)	1.21 (1.05, 1.39)	1.33 (1.14, 1.54)	1.24 (1.12, 1.38)	<0.001
Sensitivity-3	Sample	2,689	1,981	2,318	2,692	—	—
	Case	321	243	328	398	—	—
	Model	1.00 (ref)	1.01 (0.84, 1.22)	1.15 (0.97, 1.37)	1.33 (1.11, 1.6)	1.25 (1.1, 1.41)	<0.001
Sensitivity-4	Sample	4,564	3,606	4,173	4,546	—	—
	Case	617	528	712	830	—	—
	Model	1.00 (ref)	1.03 (0.97, 1.17)	1.17 (1.04, 1.32)	1.31 (1.16, 1.48)	1.23 (1.13, 1.34)	<0.001
Sensitivity-5	Sample	4,568	3,607	4,183	4,201	—	—
	Case	616	529	714	789	—	—
	Model	1.00 (ref)	1.03 (0.91, 1.17)	1.16 (1.03, 1.31)	1.31 (1.16, 1.48)	1.23 (1.13, 1.33)	<0.001

Note: Sensitivity-1: excluding participants whose (). Sensitivity-2: excluding participants whose systolic blood  mmHg or diastolic blood  mmHg (). Sensitivity-3: excluding participants with overweight and obesity (). Sensitivity-4: excluding participants with decreased eGFR (). Sensitivity-5: excluding participants with anemia (). Adjusting for age (y), sex, BMI (kg/m2), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mmol/L), triglyceride (mmol/L), low-density lipoprotein cholesterol (mmol/L), high-density lipoprotein cholesterol (mmol/L), eGFR (mL/min per 1.73 m2), alanine transferase (U/L), aspartate transferase (U/L), hemoglobin (g/L), hematocrit (109/L), red blood cell count (1012/L), white blood cell count (109/L), high-sensitivity C-reactive protein (mg/L), fasting blood glucose (mmol/L), and glycated hemoglobin A1c (%).