Modifiable Variables Are Major Risk Factors for Posttransplant Diabetes Mellitus in a Time-Dependent Manner in Kidney Transplant: An Observational Cohort Study

Table 3

Modifiable and nonmodifiable risk factors for developing PTDM including transplant-related variables.

Transplant-related variables
	PTDM (+); ()	PTDM (-); ()		OR	95% CI
					Inferior	Upper
Acute rejection (%, )	45.9% (28)	30.8% (120)	0.02	0.53	0.30	0.91
Cumulative steroid dose (mg/kg)			0.14	1.00	0.99	1.01
Tacrolimus (%, )	85.2% (52)	85% (331)	0.97	0.99	0.46	2.11
Mycophenolate of sodium (%, )	44.2% (27)	54.7% (213)	0.13	1.52	0.88	2.62
Cyclosporine (%, )	6.5% (4)	9.2% (36)	0.49	1.45	0.50	4.24
Azathioprine (%, )	49.2% (30)	39.8% (155)	0.17	0.68	0.40	1.18
Sirolimus (%, )	3.2% (2)	3.3% (13)	0.98	1.02	0.22	4.63
Everolimus (%, )	9.8% (6)	6.4% (25)	0.33	0.63	0.25	1.60
CMV infection (%, )	36% (22)	34.7% (135)	0.84	0.94	0.54	1.65
Transient hyperglycaemia (%, n)	86.8% (53)	18.5% (72)	0.0001	0.03	0.02	0.07
Delayed graft function (%, )	31.1% (19)	34.2% (133)	0.64	1.15	0.64	2.05
Hypertension (%, )	86.9% (53)	79.7% (310)	0.19	0.59	0.27	1.30
Calcium channel blockers (%, )	70.5% (43)	53.5% (208)	0.014	0.48	0.27	0.86
β-Blockers (%, )	54% (33)	41.9% (163)	0.07	0.61	0.36	1.05
at 6 months	42.6% (26)	32.9% (128)	0.14	0.66	0.38	1.14
at 1 year	55.7% (34)	38% (148)	0.01	0.49	0.28	0.84
at 2 years	41% (25)	32.4% (126)	0.19	0.69	0.40	1.12
at 3 years	52.4% (32)	25.7% (100)	0.0001	0.31	0.18	0.54
FK trough level at 1 month			0.004	1.11	1.03	1.19
FK trough level at 3 months			0.016	1.11	1.02	1.20
FK trough level at 6 months			0.009	1.12	1.03	1.22
FK trough level at 1 year			0.13	1.08	0.979	1.18
FK trough level at 2 years			0.18	1.06	0.972	1.16
FK trough level at 3 years			0.15	1.08	0.973	1.19