High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression

<div>SET domain-containing protein 8 (SETD8) interacted with specificity protein 1 (SP1). (a) Several transcription factors that interact with SETD8 (<a href="https://string-db.org">https://string-db.org</a>). (b) The interaction between SETD8 and SP1 in HUVECs was measured by immunoprecipitation. SETD8 was detected to interact with SP1 in HUVECs by Co-IP. (c) Colocalization of SETD8 and SP1 in HUVECs as detected by confocal microscopy.</div>

Journal of Diabetes Research

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Figure 4

Figure 4: High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression 