Sitagliptin and the Blood-Retina Barrier: Effects on Retinal Endothelial Cells Manifested Only after Prolonged Exposure

Table 2

Characteristics of inhibitors used.

Inhibitor	Targeted protein	IC50	Final concentrations	References	Provider^a
Sitagliptin	DPP-4	18 nM	10-1000 nM	[4]	Selleckchem
	DPP-2/QPP	100 μM
	DPP-8	48 μM
	DPP-9	100 μM
Diprotin A (Ile-Pro-Ile)	DPP-4	3 μM	1-25 μM	[31]	Tocris
	Other peptidases	>100 μM
Tivozanib (KRN951, AV-951)	VEGF receptor 1	30 nM	10 nM	[41]	Selleckchem
	VEGF receptor 2	6.5 nM
	VEGF receptor 3	15 nM
	PDGF receptor α	40 nM
	PDGF receptor β	49 nM

^aSelleckchem: Selleckchem via Absource GmbH, Munich; Tocris: Tocris via Bio-Techne. DPP: dipeptidyl peptidase; QPP: quiescent cell proline dipeptidase.