Research Article
Sitagliptin and the Blood-Retina Barrier: Effects on Retinal Endothelial Cells Manifested Only after Prolonged Exposure
Table 2
Characteristics of inhibitors used.
| Inhibitor | Targeted protein | IC50 | Final concentrations | References | Providera |
| Sitagliptin | DPP-4 | 18 nM | 10-1000 nM | [4] | Selleckchem | DPP-2/QPP | 100 μM | | | | DPP-8 | 48 μM | | | | DPP-9 | 100 μM | | | |
| Diprotin A (Ile-Pro-Ile) | DPP-4 | 3 μM | 1-25 μM | [31] | Tocris | Other peptidases | >100 μM | | | |
| Tivozanib (KRN951, AV-951) | VEGF receptor 1 | 30 nM | 10 nM | [41] | Selleckchem | VEGF receptor 2 | 6.5 nM | | | | VEGF receptor 3 | 15 nM | | | | PDGF receptor α | 40 nM | | | | PDGF receptor β | 49 nM | | | |
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aSelleckchem: Selleckchem via Absource GmbH, Munich; Tocris: Tocris via Bio-Techne. DPP: dipeptidyl peptidase; QPP: quiescent cell proline dipeptidase.
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