The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis

Figure 4

Trial sequential analysis of the pooled outcome regarding fasting blood glucose. A trial sequential analysis (TSA) showed that the pooled results ( curve; blue lines) crossed the conventional boundary of benefit (celeste line) but did not reach the required information size (599) or cross the trial sequential monitoring boundary for benefit (cumulative curve in red) to enter the area of benefit (above the upper red curve).