The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis

Table 2

Difference in secondary outcomes between the diacerein group and control group.

Index	Number of studies	Sample size of diacerein group	Sample size of control group	Mean difference (95% CI)	value	Heterogeneity (, )
HbA1c	5	140	138	-0.71 (-1.07, -0.36)	<0.001	78%, 0.001
Triglyceride	4	104	103	-7.84 (-18.14, 2.47)	0.14	10%, 0.34
Total cholesterol	3	61	62	-2.83 (-14.92, 9.26)	0.65	41%, 0.19
Low-density lipoprotein	4	104	103	3.91 (-6.53, 14.36)	0.46	69%, 0.02
High-density lipoprotein	4	104	103	-34.6 (-111.11, 41.91)	0.38	100%, <0.001
Body mass index	2	41	42	-0.40 (-0.49, -0.31)	<0.001	0%, 0.87
Hematocrit	2	78	77	0.64 (-0.16, 1.44)	0.12	49%, 0.16
Platelet count	2	78	77	1.00 (-2.09, 4.09)	0.53	0%, 0.62
C-reactive protein	2	78	77	-1.49 (-2.78, -0.19)	0.02	0%, 0.64