Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice

Table 1

Changes in BW, KW/BW, blood glucose, and insulin levels in diabetic mice after different treatments ().

	Nor	Con	Pyr	Pyr-ORS
BW (g)
Week 0			^##	^##
Week 8			^##	^##
KW/BW (mg/g)
Week 0	—	—	—	—
Week 8			^##
Glucose (mmol/l)
Week 0
Week 8			^#	^#
Insulin (ng/ml)
Week 0
Week 8			^##	^##

Nor (normal), C57BLKS/J nontreated mice; Con (control), C57BLKS/J diabetic db/db nontreated mice; Pyr, db/db mice drunk distilled water containing 1% pyruvate; Pyr-ORS, db/db mice drunk pyruvate-enriched ORS to replace distilled water, containing 0.35% pyruvate; BW: body weight; KW/BW: kidney weight/body weight; glucose: fasting plasma glucose; insulin: fasting plasma insulin; and vs. Nor; ^# and ^## vs. Con. Values were at week 0 and at week 8, respectively.