Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice

Table 3

Changes in LDH, PK, and PDHa/PDHt in kidney homogenates after different treatments ().

	Nor	Con	Pyr	Pyr-ORS
LDH (mU/mg protein)
Week 0	—	—	—	—
Week 8			^##	^##
PK (mU/mg protein)
Week 0	—	—	—	—
Week 8			^##	^#
PDHa/PDHt ratio
Week 0	—	—	—	—
Week 8			^#	^#

Nor (normal), C57BLKS/J nontreated mice; Con (control), C57BLKS/J diabetic db/db nontreated mice; Pyr, db/db mice drunk distilled water containing 1% pyruvate; Pyr-ORS, db/db mice drunk pyruvate-enriched ORS to replace distilled water, containing 0.35% pyruvate; LDH: lactate dehydrogenase; PK: pyruvate kinase; PDHa/PDHt: activities of pyruvate dehydrogenase/total pyruvate dehydrogenase. and vs. Nor; ^# and ^## vs. Con. Values were at week 0 and at week 8, respectively.