Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study
Table 3
Multivariable adjusted risk of type 2 diabetes with PM10 and polymorphism.
Model
Variables
Hazard ratio (95% CI)
value
Model 1a
PM10
1.43 (1-2.23)
0.036
Model 2b
PM10
1.43 (1.003-2.03)
0.048
rs10830963 (reference)
1
—
rs10830963 (CG)
1.35 (1.08-1.7)
0.009
rs10830963 (GG)
1.91 (1.39-2.63)
0.001
Model 3c
PM10
1.33 (0.8-2.24)
0.28
rs10830963 (reference)
1
—
rs10830963 (CG)
0.64 (0.01-39.54)
0.83
rs10830963 (GG)
0.43 (0.00-1651.1)
0.84
Interaction
1.1 (0.67-1.80)
0.72
Model 4d
PM10
1.33 (0.8-2.24)
0.06
rs10830963 (reference)
1
—
rs10830963 (CG)
1.50 (1.16-1.83)
0.001
rs10830963 (GG)
2 (1.43-2.71)
0.001
Age
1.04 (1.03-1.05)
0.001
Gender (male as reference)
1 (0.8-1.23)
0.94
Model 5e
PM10
1.50 (1.003-2.32)
0.072
rs10830963 (reference)
1
—
rs10830963 (CG)
1.65 (1.24-2.21)
0.001
rs10830963 (GG)
2.134 (1.42-3.21)
0.001
Age
1.03 (1.01-1.04)
0.001
Gender (male as reference)
1 (0.67-1.49)
0.99
BMI
1.10 (1.07-1.14)
0.001
SBP
1.01 (1.00-1.03)
0.014
DBP
1 (1.00-1.01)
0.30
LDL cholesterol
0.99(0.99-1.003)
0.60
HDL cholesterol
0.97 (0.96-0.98)
0.001
Smoking status
Never smoker (reference)
1
—
Former
0.67 (0.24-1.84)
0.44
Current
0.88 (0.5-1.55)
0.65
Education level
≤6 years (reference)
1
—
Between 7 and 12 years
1.01 (0.71-1.45)
0.95
>12 years
0.82 (0.51-1.31)
0.41
Occupy
0.94 (0.64-1.40)
0.78
Leisure_Met
1.03 (0.8-1.35)
0.8
aCrude model (PM10 alone). bModel 2 (PM10 and SNP). cModel 3 (interaction), dAdjusted for age and gender. eAdjusted for age, gender, education level, BMI, SBP, DBP, occupy, education level, smoking, Leisure_Met, and LDL and HDL cholesterol.