Journal of Diabetes Research / 2020 / Article / Tab 3

Research Article

Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study

Table 3

Multivariable adjusted risk of type 2 diabetes with PM10 and polymorphism.

ModelVariablesHazard ratio (95% CI) value

Model 1aPM101.43 (1-2.23)0.036
Model 2bPM101.43 (1.003-2.03)0.048
rs10830963 (reference)1
rs10830963 (CG)1.35 (1.08-1.7)0.009
rs10830963 (GG)1.91 (1.39-2.63)0.001
Model 3cPM101.33 (0.8-2.24)0.28
rs10830963 (reference)1
rs10830963 (CG)0.64 (0.01-39.54)0.83
rs10830963 (GG)0.43 (0.00-1651.1)0.84
Interaction1.1 (0.67-1.80)0.72
Model 4dPM101.33 (0.8-2.24)0.06
rs10830963 (reference)1
rs10830963 (CG)1.50 (1.16-1.83)0.001
rs10830963 (GG)2 (1.43-2.71)0.001
Age1.04 (1.03-1.05)0.001
Gender (male as reference)1 (0.8-1.23)0.94
Model 5ePM101.50 (1.003-2.32)0.072
rs10830963 (reference)1
rs10830963 (CG)1.65 (1.24-2.21)0.001
rs10830963 (GG)2.134 (1.42-3.21)0.001
Age1.03 (1.01-1.04)0.001
Gender (male as reference)1 (0.67-1.49)0.99
BMI1.10 (1.07-1.14)0.001
SBP1.01 (1.00-1.03)0.014
DBP1 (1.00-1.01)0.30
LDL cholesterol0.99(0.99-1.003)0.60
HDL cholesterol0.97 (0.96-0.98)0.001
Smoking status
 Never smoker (reference)1
 Former0.67 (0.24-1.84)0.44
 Current0.88 (0.5-1.55)0.65
Education level
 ≤6 years (reference)1
 Between 7 and 12 years1.01 (0.71-1.45)0.95
 >12 years0.82 (0.51-1.31)0.41
Occupy0.94 (0.64-1.40)0.78
Leisure_Met1.03 (0.8-1.35)0.8

aCrude model (PM10 alone). bModel 2 (PM10 and SNP). cModel 3 (interaction), dAdjusted for age and gender. eAdjusted for age, gender, education level, BMI, SBP, DBP, occupy, education level, smoking, Leisure_Met, and LDL and HDL cholesterol.

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