Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study

Table 3

Multivariable adjusted risk of type 2 diabetes with PM10 and polymorphism.

Model	Variables	Hazard ratio (95% CI)	value
Model 1^a	PM10	1.43 (1-2.23)	0.036
Model 2^b	PM10	1.43 (1.003-2.03)	0.048
	rs10830963 (reference)	1	—
	rs10830963 (CG)	1.35 (1.08-1.7)	0.009
	rs10830963 (GG)	1.91 (1.39-2.63)	0.001
Model 3^c	PM10	1.33 (0.8-2.24)	0.28
	rs10830963 (reference)	1	—
	rs10830963 (CG)	0.64 (0.01-39.54)	0.83
	rs10830963 (GG)	0.43 (0.00-1651.1)	0.84
	Interaction	1.1 (0.67-1.80)	0.72
Model 4^d	PM10	1.33 (0.8-2.24)	0.06
	rs10830963 (reference)	1	—
	rs10830963 (CG)	1.50 (1.16-1.83)	0.001
	rs10830963 (GG)	2 (1.43-2.71)	0.001
	Age	1.04 (1.03-1.05)	0.001
	Gender (male as reference)	1 (0.8-1.23)	0.94
Model 5^e	PM10	1.50 (1.003-2.32)	0.072
	rs10830963 (reference)	1	—
	rs10830963 (CG)	1.65 (1.24-2.21)	0.001
	rs10830963 (GG)	2.134 (1.42-3.21)	0.001
	Age	1.03 (1.01-1.04)	0.001
	Gender (male as reference)	1 (0.67-1.49)	0.99
	BMI	1.10 (1.07-1.14)	0.001
	SBP	1.01 (1.00-1.03)	0.014
	DBP	1 (1.00-1.01)	0.30
	LDL cholesterol	0.99(0.99-1.003)	0.60
	HDL cholesterol	0.97 (0.96-0.98)	0.001
	Smoking status
	Never smoker (reference)	1	—
	Former	0.67 (0.24-1.84)	0.44
	Current	0.88 (0.5-1.55)	0.65
	Education level
	≤6 years (reference)	1	—
	Between 7 and 12 years	1.01 (0.71-1.45)	0.95
	>12 years	0.82 (0.51-1.31)	0.41
	Occupy	0.94 (0.64-1.40)	0.78
	Leisure_Met	1.03 (0.8-1.35)	0.8

^aCrude model (PM10 alone). ^bModel 2 (PM10 and SNP). ^cModel 3 (interaction), ^dAdjusted for age and gender. ^eAdjusted for age, gender, education level, BMI, SBP, DBP, occupy, education level, smoking, Leisure_Met, and LDL and HDL cholesterol.