Renal Effects of Sulodexide in Type 2 Diabetic Patients without Nephrotic Range Proteinuria

Figure 1

Box-and-whisker-plot diagrams show the (a) percentage of median change of urine protein creatinine ratio and (b) percentage of median change of estimated GFR after 12 months of treatment. (a) shows the percentage of median change that decreased from baseline at -17.7% (IQR -53.1 to 3.2) in the sulodexide group and increased percentage of median change from baseline 19.4% (IQR 10.3 to 37.6) in the control group (). (b) shows that estimated GFR levels during the 12-month follow-up significantly declined by -15.5% (IQR -25.8 to -4.9) in the sulodexide group and by -12.4% (IQR -17.5 to -6.1) in the control group, but no significant difference was observed in the rate of change in estimated GFR between the two groups (). Error bars represent 95% CIs.

(a) Percentage of median change (IQR) of urine protein creatinine ratio

(b) Percentage of median change (IQR) of estimated GFR