Research Article
Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study
Table 2
The statistical difference in 11 serum metabolic biomarker candidates.
| Metabolites | Class | VIP | value | Trend | Mode | Rt | | OR (95% CI) | value | FDR-adjusted value |
| Hexadecanoic Acid (C16:0) | Lipid-free fatty acid | 6.02239 | <0.001 | UP | N | 11.65 | 256.24 | 0.2 (0.1, 0.5) | 0.002 | 0.028 | Linolelaidic Acid (C18:2N6T) | Lipid-free fatty acid | 6.25109 | <0.001 | UP | N | 11.1 | 280.24 | 0.2 (0.1, 0.5) | <0.001 | 0.016 | Linoleic Acid (C18:2N6C) | Lipid-free fatty acid | 6.05045 | <0.001 | UP | N | 11.1 | 280.24 | 0.2 (0.1, 0.6) | 0.001 | 0.018 | Trans-4-Hydroxy-L-Proline | Amino acids and their derivatives | 4.10297 | 0.004 | Down | P | 1.21 | 131.058 | 2.4 (1.3, 4.5) | 0.006 | 0.058 | 6-Aminocaproic Acid | Organic acids and their derivatives | 3.67465 | 0.001 | Down | P | 1.16 | 131.095 | 4.3 (1.8, 10.5) | 0.001 | 0.028 | L-Dihydroorotic Acid | Organic acids and their derivatives | 4.06423 | <0.001 | Down | P | 0.58 | 158.033 | 35.0 (4.0, 308.4) | 0.001 | 0.018 | 6-Methylmercaptopurine | Nucleotides and their derivatives | 3.08662 | 0.005 | Down | P | 1.85 | 166.0313 | 2.7 (1.3, 5.8) | 0.009 | 0.065 | Piperidine | — | 1.53861 | 0.002 | Down | P | 1.16 | 85.08915 | 49.3 (4.1, 589.9) | 0.002 | 0.04 | Azoxystrobin Acid | — | 1.18869 | <0.001 | UP | P | 6.99 | 389.1012 | 0.0 (0.0, 0.0) | 0.002 | 0.001 | Lysopc 20:4 | Lipid-fatty acid | 6.07644 | 0.002 | UP | P | 9 | | 0.4 (0.2, 0.7) | 0.004 | 0.03 | Cuminaldehyde | Lipid-fatty acid | 1.3433 | 0.002 | Down | P | 1.87 | 148.0888 | 14.9 (2.2, 101.8) | 0.006 | 0.04 |
|
|
VIP: variable importance in the project; N: negative mode; P: positive mode; Rt: retention time (minutes); : mass-charge ratio; FDR: false discovery rate-adjusted value. |