3β-Hydroxysteroid-Δ24 Reductase (DHCR24) Protects Pancreatic β Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species
UPR-related signaling pathways were detected after TM treatment by Western blot analysis. (a) Representative Western blots show the expression of c-myc, Bip, p-p38, ATF6, and cleaved ATF6 in MIN6 cells after TM treatment. The levels of these proteins were normalized to actin levels. (b, c) The levels of Bip, p-p38, ATF6, and cleaved ATF6 were calculated as percentage of the largest level in the negative control (Ad-LacZ) group. (); vs. Ad-LacZ.
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