Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes

Figure 1

TSF reduced proteinuria and alleviated renal injury in db/db mice. (a) Body weight was recorded each week (). (b) Kidney weight of mice in each group at 22 weeks of age (). (c) Urinary albumin to creatinine ratio (ACR) (). (d) Serum creatinine in each group (). (e) Representative PAS staining (scale bars, 20 μm) and quantitative analysis of glomerular hypertrophy and mesangial expansion (); representative PASM staining (scale bars, 20 μm). (f) Representative immunohistochemical staining and quantitative analysis of collagen type IV and fibronectin (scale bars, 20 μm) (20 glomeruli were randomly evaluated per section) (). The data were expressed as the . ^#, ^## vs. db/m group; , vs. db/db group. Statistically analyzed via a one-way ANOVA with Dunnett’s correction.

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