Association of Maternal Diabetes Mellitus and Polymorphisms of the NKX2.5 Gene in Children with Congenital Heart Disease: A Single Centre-Based Case-Control Study
Table 5
Multivariate analysis of NKX2.5 gene polymorphism and CHD.
NKX2.5 gene
B
S.E
Wals
value
Adjusted OR (95% CI)
Genotype at rs6882776 ()
G/A
0.082
0.169
0.238
0.626
1.09 (0.78-1.51)
G/G
0.018
0.239
0.006
0.940
1.02 (0.64-1.63)
Additive model
0.026
0.114
0.050
0.822
1.03 (0.82-1.28)
Recessive model
0.068
0.161
0.179
0.673
1.07 (0.78-1.47)
Dominant model
-0.031
0.217
0.020
0.886
0.97 (0.63-1.48)
Genotype at rs118026695 ()
C/T
0.766
0.196
15.297
0.001
2.15 (1.47-3.16)
C/C
1.603
0.707
5.147
0.023
4.97 (1.24-19.86)
Additive model
0.774
0.175
19.521
0.001
2.17 (1.54-3.06)
Recessive model
0.821
0.191
18.546
0.001
2.27 (1.56-3.30)
Dominant model
1.450
0.704
4.241
0.039
4.26 (1.07-16.95)
Genotype at rs2277923 ()
T/C
0.477
0.167
8.127
0.004
1.61 (1.16-2.24)
T/T
0.555
0.240
5.352
0.021
1.74 (1.09-2.79)
Additive model
0.328
0.113
8.478
0.004
1.39 (1.11-1.73)
Recessive model
0.496
0.158
9.840
0.002
1.64 (1.20-2.24)
Dominant model
0.302
0.222
1.842
0.175
1.35 (0.88-2.09)
Genotype at rs703752 ()
C/A
0.467
0.970
0.232
0.630
1.60 (0.24-10.68)
C/C
0.893
0.947
0.889
0.346
2.44 (0.38-15.63)
Additive model
0.430
0.212
4.098
0.043
1.54 (1.01-2.33)
Recessive model
0.452
0.229
3.908
0.048
1.57 (1.00-2.46)
Dominant model
0.847
0.946
0.802
0.371
2.33 (0.37-14.90)
OR: odds ratio; CI: confidence interval; SNP: single-nucleotide polymorphism; CHD: congenital heart disease. Adjusted for factors with statistical differences in Table 1.
