Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes

Table 3

Influence factors of one-year euglycemia remission.

	Odds ratio	95% CI for OR	value
(A) Overall analysis
Gender	1.342	0.632~2.850	0.444
Age	0.992	0.961~1.024	0.616
BMI at baseline	1.055	0.949~1.172	0.323
HDL-C at baseline	0.446	0.123~1.613	0.218
Mild hypoglycemia (3.0~3.9 mmol/L)	2.184	1.015~4.699	0.046
Mean insulin dose (IU/day)	0.992	0.962~1.023	0.605
FPG after treatment	0.641	0.456~0.902	0.011
PPG after treatment	0.912	0.787~1.056	0.217
AIR after treatment	1.000	1.000~1.001	0.849
HOMA-IR after treatment	0.976	0.807~1.181	0.806
(B) Stratified analysis
Gender	1.439	0.673~3.077	0.348
Men
Women
Age (years)	0.901	0.588~1.380	0.633
<45
45-55
>55
BMI at baseline (kg/m^2)	1.062	0.639~1.767	0.816
<24
24-28
>28
HDL-C at baseline (mmol/L)	0.623	0.305~1.269	0.192
<1.0
≥1.0
Total episodes of mild hypoglycemia	1.593	1.153~2.201	0.005
None
1-2
3-5
>5
Mean insulin dose (IU/day)	0.903	0.509~1.600	0.726
<30
30-40
>40
FPG after treatment (mmol/L)	0.661	0.442~0.989	0.044
<5.0
5.0-6.0
6.1-7.0
>7.0
PPG after treatment (mmol/L)	0.697	0.467~1.039	0.076
<6.0
6.0-8.0
8.1-10.0
>10.0
AIR after treatment (pmol/L·10 min)	1.333	0.718~2.472	0.362
<0
0-430
>430
HOMA-IR after treatment	1.271	0.666~2.426	0.466
<2.25
≥2.25

means . BMI: body mass index; FPG: fasting plasma glucose; PPG: postprandial plasma glucose; HDL-C: high-density lipoprotein cholesterol; AIR: acute insulin response; HOMA-IR: homeostasis model assessment of insulin resistance. The median levels of AIR and HOMA-IR were 430 pmol/L·10 min and 2.25, respectively. Age, BMI, HDL-C, total episodes of mild hypoglycemia, mean insulin dose, FPG, and PPG were stratified according to the characteristics of clinical indicators. AIR and HOMA-IR were stratified based on the median levels.