Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study
Table 2
Laboratory findings.
CBC (D2)
Biochemistry measurements (D2 and D5)
Immunological tests (D8 and D23)
WBC (/μL)
6800
Na (mEq/L)
133
IgA (mg/dL)
361
Hb (g/dL)
10.9
K (mEq/L)
5.1
IgG (mg/dL)
1068
Plt (×103/mL)
20.3
Cl (mEq/L)
106
IgM (mg/dL)
28
BUN (mg/dL)
29.7
C3 (mg/dL)
61
Urinalysis (D1)
Cr (mg/dL)
2.00
C4 (mg/dL)
20
pH
6.0
TP (g/dL)
6.5
CH50 (U/mL)
49.3
Blood
+-
Alb (g/dL)
3.3
RF
–
Glucose
4+
CRP (mg/dL)
0.18
ANA (titer)
–
Protein
2+
Cortisol (μg/dL)
14.1
Cytoplasmic type
+
Ketones
–
Free T4 (ng/dL)
1.44
ssDNA Ab (AU/mL)
11.0
TP/Cr (mg/g·Cr)
1792.2
TSH (mU/mL)
0.84
dsDNA Ab (IU/mL)
<5.0
SS-A (index)
1.1
Diabetes-related measurements (D1–D3 and D10)
Endocrinology measurements (D9 and D10)
SS-B (index)
1.8
FBG (mg/dL)
538
ACTH (pg/mL)
8.45
Sm Ab (index)
2.1
FBG (mmol/L)
29.9
PRA (ng/mL/h)
1.9
RNP Ab (index)
5
Fasting IRI (μU/mL)
Impossible to measure#
ALDS (pg/mL)
81
MPO-ANCA (IU/mL)
0.5
Fasting CPR (ng/mL)
10.3
CS (μg/dL)
14.1
PR3-ANCA (IU/mL)
0.5
Proinsulin (pmol/L) (D10)
942
GH (ng/mL)
0.842
HbA1c (%)
7.2
SM-C (ng/mL)
48
HbA1c (mmol/mol)
55.2
U-metanephrine (mg/L)
0.02##
Glycoalbumin (%)
28.1
U-normetanephrine (mg/L)
0.11##
Anti-GAD Ab (U/mL)
<0.3
U-cortisol (μg/L)
13.0##
Anti-insulin Ab (%)
7.4
IA-2 Ab (U/mL)
0.8
Anti-insulin receptor Ab (%)
71.3
Ab: antibody; ACTH: adrenocorticotropic hormone; ALDS: aldosterone; ANA: antinuclear antibody; BG: blood glucose; CPR: C-peptide; CRP: C-reactive protein; CS: cortisol; dsDNA Ab: double-stranded DNA antibodies; GAD: glutamic acid decarboxylase; Hb: hemoglobin; IA-2: islet antigen 2; IRI: immunoreactive insulin; PRA: plasma renin activity; GH: growth hormone; MPO: myeloperoxidase; Plt: platelet; PR3: proteinase-3; RF: rheumatoid factor; RNP Ab: ribonucleoprotein antibodies; ssDNA Ab: single-stranded DNA antibodies; Sm Ab: Smith antibodies; SM-C: somatomedin C; TP/Cr: total protein/creatinine; TSH: thyroid-stimulating hormone; WBC: white blood cell. Above the reference range; below the reference range; #it was considered impossible to measure due to the extremely high value and the influence of insulin antibody; ##because the urine collection test was not allowed at our hospital at that time, these items were evaluated using early morning urine.
