Research Article

Risk Factors for Cognitive Impairment in Patients with Type 2 Diabetes

Table 1

Demographic and clinical characteristics of the 120 T2DM patients grouped according to the degree of cognitive impairment.

CharacteristicsNCF group ()MCI group ()MoCI group ()SCI group () value

Age (y)11.2430.012
Duration of diabetes (y)14.350.008
Smoking (%)15 (37.50%)18 (48.65%)23 (74.19%)9 (75.00%)8.5320.018
Education level (y)33 (82.50%)24 (64.86%)12 (38.71%)4 (33.33%)9.1350.013
Cardiovascular event13 (32.50%)15 (40.54%)16 (51.61%)7 (58.33%)7.3570.042
TC (mmol/L)3.42 (3.34, 4.32)3.33 (3.24, 4.56)3.84 (3.12, 4.78)4.51 (3.56, 5.78)12.5050.002
TG (mmol/L)2.51 (1.23, 3.21)2.71 (1.34, 3.67)3.13 (1.56, 4.56)4.24 (1.67, 5.32)13.870.004
HDL-C (mmol/L)2.2010.117
LDL-C (mmol/L)2.350.102
BMI (kg/m2)1.8240.048
SBP (mmHg)3.9550.138
DBP (mmHg)2.5380.281
FBG (mmol/L)10.2660.044
HbA1c (mmol/L)12.5510.002
AST (U/L)31.55 (13.45, 38.54)23.00 (18.65, 41.42)25.70 (20.12, 43.56)
ALT (U/L)21.2 (10.34, 25.67)43.70 (32.45, 48.64)2.2390.1132.9260.134
ALP (U/L)72.75 (50.46, 89.44)71.45 (43.45, 89.34)81.34 (68.34, 99.34)85.34 (72.39, 91.77)2.5090.285
Prealbumin (g/L)0.26 (0.21, 0.43)0.27 (0.22, 0.34)0.21 (0.15, 0.29)0.25 (0.17, 0.23)4.9820.544
Apo-A1 (g/L)0.93 (0.67, 1.31)0.95 (0.71, 1.23)1.05 (0.73, 1.22)1.03 (0.75, 1.32)3.4560.436
Apo-B (g/L)0.96 (0.94, 1.03)0.98 (0.95, 1.04)0.83 (0.78, 0.88)0.92 (0.85, 0.97)2.4560.754
T Bil (μmol/L)1.3450.435
I Bil (μmol/L)2.4520.654
D Bil (μmol/L)3.42 (3.21, 3.56)2.91 (2.34, 3.56)3.31 (2.67, 3.97)2.54 (2.14, 3.08)5.3560.267
TBA (μmol/L)1.3750.135
WBC6.31 (4.87, 7.46)7.54 (5.36, 8.46)6.04 (5.03, 7.98)7.04 (5.35, 9.75)3.4670.079
NE%0.60 (0.45, 0.71)0.51 (0.43, 0.76)0.56 (0.51, 0.68)0.62 (0.55, 0.73)2.3490.275
LY%0.33 (0.25, 0.38)0.31 (0.27, 0.39)0.37 (0.33, 0.41)0.41 (0.36, 0.49)0.9230.319
24 h UP (g/24 h)15.5630.014
24 h mAlb (mg/24 h)3.5610.145
CRP (mg/L)3.35 (2.34, 5.42)4.36 (3.45, 5.78)3.22 (2.45, 4.67)3.52 (2.67, 4.66)2.3450.542
SCr (μmol/L)72.6 (63.46, 77.54)77.56 (72.45, 79.54)63.42 (54.67, 69.13)73.34 (65.88, 78.64)1.3860.638
BUN (mmol/L)5.23 (4.24, 6.75)6.21 (5.78, 6.94)5.61 (4.35, 7.68)5.11 (4.24, 6.97)2.4570.846
UA (μmol/L)8.6420.063
Alb (g/L)38.21 (33.56, 41.34)40.41 (35.78, 43.67)39.52 (32.56, 42.87)35.64 (31.56, 40.23)5.6820.105
Glb (g/L)28.23 (25.78, 30.14)28.23 (23.56, 32.67)23.54 (21.38, 27.58)25.45 (22.46, 26.95)2.8430.638
CO2CP (mmol/L)25.62 (23.55, 27.54)25.33 (21.45, 29.45)26.29 (24.56, 29.76)27.23 (25.32, 30.12)0.4680.462
CHE (U/L)0.2460.723

. Abbreviations: TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density cholesterol.