Thyroid Parameters and Kidney Disorder in Type 2 Diabetes: Results from the METAL Study
Table 2
Association of thyroid parameters with UACR and eGFR by linear regression.
lnUACR
lneGFR
(95% CI)
P
(95% CI)
P
Total participants
TSH
0.014 (-0.004, 0.033)
0.136
-0.007 (-0.010, -0.004)
<0.001
FT3
-0.171 (-0.242, -0.099)
<0.001
0.069 (0.057, 0.080)
<0.001
FT4
0.008 (-0.010, 0.025)
0.399
-0.003 (-0.006, 0.000)
0.031
T3
-0.269 (-0.408, -0.130)
<0.001
0.096 (0.074, 0.118)
<0.001
T4
0.000 (-0.002, 0.002)
0.896
-0.000 (-0.000, 0.000)
0.752
TPOAb positive
0.092 (-0.054, 0.238)
0.215
-0.023 (-0.046, 0.000)
0.053
TgAb positive
-0.004 (-0.168, 0.160)
0.961
-0.029 (-0.056, -0.003)
0.028
Euthyroid participants
TSH
-0.029 (-0.080, 0.021)
0.258
-0.004 (-0.011, 0.003)
0.304
FT3
-0.124 (-0.214, -0.033)
0.008
0.046 (0.034, 0.059)
<0.001
FT4
0.011 (-0.012, 0.033)
0.354
-0.005 (-0.008, -0.002)
0.001
T3
-0.088 (-0.269, 0.092)
0.337
0.045 (0.020, 0.070)
<0.001
T4
0.002 (-0.001, 0.004)
0.264
-0.001 (-0.001, 0.000)
0.002
TPOAb positive
-0.005 (-0.186, 0.177)
0.958
-0.004 (-0.029, 0.022)
0.782
TgAb positive
-0.024 (-0.231, 0.184)
0.822
-0.031 (-0.060, -0.002)
0.033
UACR and eGFR were ln-transformed for normal distribution before linear regression analysis. The regression models were adjusted for age, sex, HbA1c, BMI, urine acid, the duration of diabetes, current smoking, dyslipidemia, hypertension, and current use metformin.
