Thyroid Parameters and Kidney Disorder in Type 2 Diabetes: Results from the METAL Study
Table 4
Associations of thyroid homeostasis parameters with kidney disorders.
Reduced eGFR
Higher UACR
Higher UACR or reduced eGFR
OR (95% CI)
OR (95% CI)
OR (95% CI)
Total participants
SPINA-GD
0.801 (0.754, 0.852)
<0.001
0.951 (0.926, 0.977)
<0.001
0.935 (0.910, 0.960)
<0.001
SPINA-GT
0.993 (0.937, 1.052)
0.814
1.013 (0.994, 1.032)
0.187
1.012 (0.994, 1.030)
0.197
TSHI
1.349 (1.021, 1.783)
0.035
1.027 (0.896, 1.178)
0.703
1.050 (0.917, 1.202)
0.479
TTSI
1.001 (1.000, 1.002)
0.018
1.000 (1.000, 1.001)
0.294
1.000 (1.000, 1.001)
0.276
Euthyroid participants
SPINA-GD
0.831 (0.755, 0.913)
<0.001
0.961 (0.926, 0.996)
0.031
0.947 (0.914, 0.982)
0.003
SPINA-GT
1.054 (0.866, 1.283)
0.601
1.064 (0.973, 1.162)
0.173
1.065 (0.976, 1.162)
0.157
TSHI
1.449 (0.934, 2.248)
0.098
1.000 (0.821, 1.218)
0.999
1.017 (0.837, 1.235)
0.866
TTSI
1.000 (1.000, 1.000)
0.437
1.000 (1.000, 1.000)
0.538
1.000 (1.000, 1.000)
0.501
They were analyzed by using logistic regression. The regression models were adjusted for age, sex, HbA1c, BMI, UA, the duration of diabetes, current smoking, dyslipidemia, hypertension, and current use of metformin.
