Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy

Table 1

Data of the study sample used for calculating the principal component scores at 12+0 to 22+6 (V1), 24+0 to 28+6 weeks of gestation (V2), and 2 to 11 months after delivery (V3).

		V1		V2		V3	value^§
Age (years)	67		62	^#	25	^#	<0.001
BMI (kg/m^2)	67		57	^#	23		<0.001
BMI (kg/m^2)^†	67		57	^#	23		<0.001
G0 (mg/dl)	67		61		23	^#	0.003
G30 (mg/dl)	67		59		23		0.181
G60 (mg/dl)	67		59	^#	23		<0.001
G90 (mg/dl)	67		59	^#	23		<0.001
G120 (mg/dl)	67		59		23		0.055
I0 (μU/ml)	67		59		23	^#	0.001
I30 (μU/ml)	67		57		23		0.239
I60 (μU/ml)	67		57		23		0.157
I90 (μU/ml)	67		57		23		0.104
I120 (μU/ml)	67		57		23	^#	<0.001
CP0 (ng/ml)	67		59	^#	23		<0.001
CP30 (ng/ml)	67		57	^#	23		0.015
CP60 (ng/ml)	67		57	^#	23		<0.001
CP90 (ng/ml)	67		57	^#	23		<0.001
CP120 (ng/ml)	67		57	^#	23		<0.001
QUICKI (dimensionless)	67		59		23	^#	0.007
ISI-Matsuda (dimensionless)	67		57		23	^#	<0.001
OGIS (ml/min m^-2)	67		57		23		0.086
TIS (nmol/m)	67		57	^#	23		<0.001
PCS1	67		57	^#	23	^#	<0.001
PCS2	67		57		23		0.170
PCS3	67		57		23	^#	0.032

Data are expressed as . BMI: body mass index. Values are given for glucose (G), insulin (I), and C-peptide (CP) for fasting as well as 30, 60, 90, and 120 minutes after oral glucose load. QUICKI: quantitative insulin sensitivity check index; ISI-Matsuda: Matsuda index; OGIS: oral glucose insulin sensitivity index; TIS: total insulin secretion from C-peptide; PCS: principal component scores 1–3. Log transformation (natural logarithm). ^†BMI (original units). Square root transformation. ^# vs. V1. ^§Test for global hypothesis: V1 vs. V2 vs. V3.