ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease

Table 2

Meta-analysis of the association between the ADIPOQ rs2241766 polymorphism and DKD risk.

Model	Ethnicity			Type			Total	No. of studies and participants
	Caucasian	Asian	African	T1DM	T2DM	T2DM or T1DM
GG vs. TT
OR (95% CI)	1.31 (0.92, 1.87)	1.21 (0.78, 1.86)	9.06 (3.00, 27.34)	1.18 (0.54, 2.56)	1.79 (1.26, 2.55)	1.27 (0.82, 1.95)	1.51 (1.16, 1.95)	12 (324/7417)
Ph	0.709	0.503	/	0.945	0.016	/	0.098
test	0.0%	0.0%	/	0.0%	61.6%	/	36.6%
GG + TG vs. TT
OR (95% CI)	1.27 (1.01, 1.60)	0.86 (0.69, 1.07)	4.80 (2.86, 8.03)	0.99 (0.80, 1.24)	1.25 (0.81, 1.93)	1.15 (0.96, 1.37)	1.12 (0.90, 1.40)	14 (3218/7987)
Ph	0.006	0.864	/	0.312	0.000	/	0.000
test	62.9%	0.0%	/	16.1%	83.0%	/	72.9%
GG vs. TT+TG
OR (95% CI)	1.26 (0.88, 1.79)	1.34 (0.88, 2.03)	4.34 (1.48, 12.68)	1.15 (0.53, 2.50)	1.68 (1.18, 2.39)	1.22 (0.79, 1.87)	1.43 (1.11, 1.85)	12 (324/10185)
Ph	0.800	0.483	/	0.955	0.229	/	0.537
test	0.0%	0.0%	/	0.0%	26.1%	/	0.0%
G vs. T
OR (95% CI)	1.12 (1.01, 1.25)	0.95 (0.80, 1.14)	3.16 (2.12, 4.71)	1.05 (0.87, 1.26)	1.19 (0.81, 1.75)	1.13 (0.97, 1.31)	1.13 (0.93, 1.38)	12 (3416/17602)
Ph	0.245	0.690	/	0.540	0.000	/	0.000
test	24.1%	0.0%	/	0.0%	82.8%	/	71.4%
TG vs. TT
OR (95% CI)	1.12 (0.98, 1.27)	0.81 (0.65, 1.02)	4.26 (2.50, 7.28)	1.04 (0.85, 1.27)	1.18 (0.72, 1.91)	1.13 (0.94, 1.36)	1.11 (0.88, 1.40)	12 (1937/5273)
Ph	0.547	0.885	/	0.580	0.000	/	0.000
test	0.0%	0.0%	/	0.0%	82.7%	/	70.3%

Note: Ph: value of heterogeneity; if Ph is >0.05, a fixed-effect model was used to calculate OR and 95% CI; otherwise, a random-effect model was used.