Research Article

Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy

Figure 8

Prediction of TFs for hub DEGs. The master TFs of hub DEGs were predicted using the iRegulon plugin in Cytoscape. The criteria for motif enrichment analysis were set as identity between orthologous , FDR on motif , and normalized enrichment score . As shown, a total of 11 TFs (Rara, Arid5a, Neurod1, Nf1, Hoxa9, Kdm2a, Smad3, Esr2, Plagl1, Gfi1b, and Pbx3) were predicted to regulate 9 of the 13 hub DEGs.