Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy
Table 2
Top 10 up- and downregulated DEGs based on fold change.
Gene symbol
Genbank accession
Fold change
Regulation
value
Mmp12
NM_053963
90.673
Up
0.0000
Ucn2
NM_133385
44.201
Up
0.0002
Cxcl2
NM_053647
21.200
Up
0.0000
C3
NM_016994
18.631
Up
0.0006
Tagln3
NM_031676
12.766
Up
0.0005
Notch1
NM_001105721
12.491
Up
0.0003
Scn3b
NM_139097
11.931
Up
0.0008
Cthrc1
NM_172333
11.618
Up
0.0003
Atp6v0d2
NM_001011972
11.413
Up
0.0001
Eltd1
AF192402
11.019
Up
0.0002
Lrrn1
NM_001037363
10.994
Down
0.0005
Hapln2
NM_022285
8.858
Down
0.0000
Lpl
NM_012598
8.382
Down
0.0003
Cdo1
NM_052809
8.091
Down
0.0000
Dbh
NM_013158
8.064
Down
0.0000
Pmp2
NM_001109514
7.860
Down
0.0001
Lrp2
NM_030827
7.805
Down
0.0000
Col9a2
NM_001108675
7.737
Down
0.0003
Hist1h4b
NM_022686
7.316
Down
0.0000
Efhd1
NM_001109310
7.291
Down
0.0006
As shown, Mmp12 was the most upregulated gene with a fold change of 90.673 and Lrrn1 was the most downregulated gene with a fold change of 10.994 among those identified DEGs.
