Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy
Table 3
GO (BP) and KEGG pathway enrichment analyses of the 3 modules.
Term
Genes
value
Module 1: GO (BP)
Cell division
Ccnb1, Cdk1, Ncaph, Spag5, Nuf2, Bub1b, Spdl1
0.0000
Protein localization to kinetochore
Cdk1, Bub1b, Ttk, Spdl1
0.0000
Mitotic chromosome condensation
Ncaph, Ncapg, Nusap1
0.0058
Protein phosphorylation
Ccnb1, Cdk1, Bub1, Bub1b, Ttk, Pbk
0.0078
Mitotic cell cycle
Ccnb1, Cdk1, Rrm2
0.0378
Module 1: KEGG pathway
Cell cycle
Ccnb1, Cdk1, Bub1, Bub1b, Ttk
0.0000
p53 signaling pathway
Ccnb1, Cdk1, Rrm2
0.0051
Progesterone-mediated oocyte maturation
Ccnb1, Cdk1, Bub1
0.0055
Oocyte meiosis
Ccnb1, Cdk1, Bub1
0.0064
Module 2: GO (BP)
Chemokine-mediated signaling pathway
Cxcl2, Cx3cr1, Ccl9, Ccl19
0.0200
Positive regulation of ERK1 and ERK2 cascade
Npy, C3, Ccl9, Ccl19, Gas6
0.0161
Neuropeptide signaling pathway
Npy, Oprk1, Npw, Npy1r
0.0323
Module 2: KEGG pathway
Chemokine signaling pathway
Gnai1, Cxcl2, Cx3cr1, Ccl9, Ccl19
0.0060
Module 3: GO (BP)
Response to drug
Lpl, CD36, Pparg, Pemt, Fabp4, Adipoq
0.0000
Cellular response to insulin stimulus
CD36, Pparg, Adipoq, Lpin1
0.0034
Fatty acid oxidation
CD36, Pparg, Adipoq
0.0023
Brown fat cell differentiation
Pparg, Fabp4, Adipoq
0.0080
Fatty acid metabolic process
CD36, Pparg, Fabp4
0.0200
Module 3: KEGG pathway
PPAR signaling pathway
Lpl, CD36, Pparg, Fabp4, Adipoq, RGD1565355
0.0000
Glycerophospholipid metabolism
Cept1, Pemt, Lpcat3, Lpin1
0.0016
AMPK signaling pathway
CD36, Pparg, Adipoq, RGD1565355
0.0025
Adipocytokine signaling pathway
CD36, Adipoq, RGD1565355
0.0174
GO (BP) and KEGG pathway enrichment analyses of the 3 modules demonstrated that the 3 most highly connected clusters in the PPI network were enriched in GO (BP) items or KEGG pathways including “cell division,” “cell cycle,” “protein phosphorylation,” “chemokine signaling pathway,” “neuropeptide signaling pathway,” “response to drug,” “cellular response to insulin stimulus,” “PPAR signaling pathway,” and “glycerophospholipid metabolism”.
