Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy

Table 4

Hub DEGs/nodes of the PPI network.

Rank	Node	Connectivity degree	Regulation
Based on DEGs of module 1
1	Cdk1	44	Up
2	Bub1b	32	Up
3	Ccnb1	32	Up
Based on the remaining DEGs of the PPI network
1	C3	25	Up
2	Agt	17	Down
3	Cxcl2	17	Up
4	Gnai1	16	Down
5	Mapk3	15	Down
6	Ccl9	14	Up
7	Cst3	14	Down
8	Cx3cr1	14	Up
9	Mmp9	13	Up
10	Npy	12	Down

Hub DEGs of the PPI network were identified using the CytoHubba plugin in Cytoscape. A total of 13 DEGs (3 from module 1: Cdk1, Bub1b, and Ccnb1; 10 from the remaining DEGs: C3, Agt, Cxcl2, Gnail, Mapk3, Ccl9, Cst3, Cx3cr1, Mmp9, and Npy) with higher connectivity degree were identified as the overall hub DEGs of the whole PPI network.