Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy

Table 5

TF prediction of the hub DEGs.

TF	NES	No. of targets	No. of motifs
Nf1	7.519	7 (C3, Cxcl2, Bub1b, Mapk3, Npy, Gnail, Agt)	5
Kdm2a	7.270	3 (C3, Npy, Gnail)	3
Smad3	6.683	3 (C3, Npy, Agt)	2
Pbx3	6.324	3 (Npy, Gnail, Agt)	5
Rara	6.269	6 (Cx3cr1, Bub1b, Mapk3, Npy, Gnail, Agt)	9
Neurod1	6.069	5 (Bub1b, Cst3, Npy, Gnail, Agt)	3
Gfi1b	5.475	4 (C3, Bub1b, Npy, Agt)	2
Hoxa9	5.392	3 (Cxcl2, Bub1b, Gnail)	2
Esr2	5.392	3 (C3, Gnail, Agt)	4
Arid5a	5.364	7 (Cxcl2, Bub1b, Cst3, Mapk3, Npy, Gnail, Agt)	6
Plagl1	5.316	3 (Bub1b, Npy, Agt)	2

TF prediction of the hub DEGs was performed using the iRegulon plugin in Cytoscape with the criteria for motif enrichment analysis as follows: identity between orthologous , FDR on motif , and normalized enrichment score . Eleven TFs (Nf1, Kdm2a, Smad3, Pbx3, Rara, Neurod1, Gfi1b, Hoxa9, Esr2, Arid5a, and Plagl1) were predicted to regulate 9 of the 13 hub DEGs.