Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes

Table 2

Genotype and allele frequency of SNPs in PNPLA2 between DM controls () and DKD patients ().

	Genotype frequencies						Allele frequencies
PNPLA2 rs28633403	AA	AG	GG	HWE value			A	G
DM	117 (26.7%)	224 (51.0%)	98 (22.3%)	0.639	0.017		458 (52.2%)	420 (47.8%)	0.015
DKD	136 (35.9%)	169 (44.6%)	74 (19.5%)	0.103			441 (58.2%)	317 (41.8%)
PNPLA2 rs1138714	AA	AG	GG	HWE value			A	G
DM	225 (51.3%)	180 (41.0%)	34 (7.7%)	0.809	0.029		630 (71.8%)	248 (28.2%)	0.018
DKD	159 (42.0%)	185 (48.8%)	35 (9.2%)	0.069			503 (66.4%)	255 (33.6%)
PNPLA2 rs1138693	TT	TC	CC	HWE value			T	C
DM	178 (40.5%)	204 (46.5%)	57 (13.0%)	0.903	0.966		560 (63.8%)	318 (36.2%)	0.845
DKD	157 (41.4%)	173 (45.6%)	49 (12.9%)	0.901			487 (64.2%)	271 (35.8%)

indicates statistical significance. HWE: Hardy-Weinberg equilibrium.