Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes

Table 4

The combined effect of PNPLA2 rs28633403 and rs1138714 polymorphisms on DKD.

Genotypes		DM	DKD	Without adjustment		With adjustment^¶
PNPLA2 rs28633403	PNPLA2 rs1138714	439	379	OR (95% CI)		OR (95% CI)
GG	AA	91	66	1^#	—	1^#	—
AG	AA	98	69	0.971 (0.624-1.510)	0.895	1.049 (0.651-1.690)	0.844
AA	AA	36	24	0.919 (0.501-1.685)	0.785	0.836 (0.432-1.618)	0.595
GG	AG+GG	7	8	1.576 (0.544-4.561)	0.402	1.270 (0.415-3.889)	0.676
AG	AG+GG	126	100	1.094 (0.725-1.651)	0.668	1.140 (0.730-1.780)	0.563
AA	AG+GG	81	112	1.906 (1.244-2.921)	0.003	2.194 (1.378-3.492)	0.001^,Δ

Abbreviations: ORs: odds ratios; CI: confidence interval. ^#Reference category (odds ratio, 1.0); adjustment for age, BMI, SBP, DBP, A1C, Hcy, TC, and TG; value < 0.05 indicates statistical significance. Δ indicates statistical significance by Holm-Bonferroni correction.