Change in Viability and Function of Pancreatic Islets after Coculture with Mesenchymal Stromal Cells: A Systemic Review and Meta-Analysis

Table 3

Meta-analysis of cytokines outcomes in studies that compared islets cultured alone with islets cocultured with MSCs.

Outcome	Studies reported outcome		Meta-analysis			(%)
	Number	Unit	Mean difference	95% CI
VEGF	4	pg/μL	-1.19	-2.25~-0.14	0.03	100
Excluding indirect	4	pg/μL	-1.82	-3.34~-0.30	0.02	100
TNF-α	3	pg/mL	2.70	-0.50~5.91	0.10	91
Excluding indirect	3	pg/mL	1.86	-3.53~7.24	0.50	93
IL-6	3	pg/mL	-1225.66	-2044.47~-406.86	0.003	100

Note. CI = confidence interval; VEGF = vascular endothelial growth factor; IL-6 = interleukin-6; TNF-α = tumor necrosis factor-α.