Uncovering the Mechanism of Astragalus membranaceus in the Treatment of Diabetic Nephropathy Based on Network Pharmacology

Table 2

Information on potential targets and the topological attributes.

No.	Gene name	Protein name	UniProt ID	Degree
1	VEGFA	Vascular endothelial growth factor A	P15692	41
2	TNF	Tumor necrosis factor	P01375	40
3	IL-6	Interleukin-6	P05231	39
4	MAPK1	Mitogen-activated protein kinase 1	P28482	37
5	CCL2	C-C motif chemokine 2	P13500	35
6	PTGS2	Alcohol dehydrogenase 1B	P35354	34
7	IL-1β	Interleukin-1 beta	P01584	34
8	NOS3	Nitric oxide synthase, endothelial	P29474	34
9	JUN	Transcription factor AP-1	P05412	34
10	EGFR	Epidermal growth factor receptor	P00533	33
11	MAPK8	Mitogen-activated protein kinase 8	P45983	33
12	IL-10	Interleukin-10	P22301	31
13	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	31
14	CXCL8	Interleukin-8	P10145	31
15	MMP2	72 kDa type IV collagenase	P08253	30
16	ESR1	Estrogen receptor	P03372	30
17	SERPINE1	Plasminogen activator inhibitor 1	P05121	30
18	TGFB1	Transforming growth factor beta-1	P01137	28
19	SIRT1	NAD-dependent deacetylase sirtuin-1	Q96EB6	28
20	MAPK14	Mitogen-activated protein kinase 14	Q16539	28
21	HIF-1α	Hypoxia-inducible factor 1-alpha	Q16665	28
22	CAV1	Caveolin-1	Q03135	26
23	SPP1	Osteopontin	P10451	25
24	MPO	Myeloperoxidase	P05164	25
25	MMP3	Stromelysin-1	P08254	24
26	KDR	Vascular endothelial growth factor receptor 2	P35968	24
27	NOS2	Nitric oxide synthase, inducible	P35228	23
28	SOD1	Superoxide dismutase (Cu-Zn)	P00441	23
29	NFE2L2	Nuclear factor erythroid 2-related factor 2	Q16236	21
30	GJA1	Gap junction alpha-1 protein	P17302	20
31	CDKN1A	Cyclin-dependent kinase inhibitor 1	P38936	19
32	IL-1A	Interleukin-1 alpha	P01583	16
33	PRKCA	Protein kinase C alpha type	P17252	15
34	PPARA	Peroxisome proliferator–activated receptor alpha	Q07869	14
35	IGF2	Insulin-like growth factor II	P01344	14
36	PTGS1	Prostaglandin G/H synthase 1	P23219	13
37	HSPA5	78 kDa glucose-regulated protein	P11021	12
38	DPP4	Dipeptidyl peptidase IV	P27487	11
39	PRKCB	Protein kinase C beta type	P05771	10
40	THBD	Thrombomodulin	P07204	10
41	AKR1B1	Aldose reductase	P15121	8
42	PON1	Serum paraoxonase/arylesterase 1	P27169	8
43	INSR	Insulin receptor	P06213	8
44	BCL2	Apoptosis regulator Bcl-2	P10415	7
45	E2F1	Transcription factor E2F1	Q01094	6
46	LYZ	Lysozyme	P61626	5
47	HTR2A	5-hydroxytryptamine 2A receptor	P28223	1
48	PRSS1	Trypsin-1	P07477	1