Study Main entry criteria Intervention treatment Control treatment Additional treatments in both groups Primary outcome Follow-up, weeks Brigido et al. [21 ] DFU: Full thickness, > 1 cm2 in size, present for ≥6 weeks without epidermal coverage, on the leg or foot Received a single application of the GJ-ADM ST: Curasol wound gel, gauze dressings Offloading, debridement NR 4 Brigido et al. [22 ] T1/T2DM; DFU: Full thickness, chronic (present for ≥6 weeks without epidermal coverage), absence of active infection Received a single application of the GJ-ADM ST: Wound gel Sharp debridement, dressing, offloading NR 16 Reyzelman et al. [23 ] T1/T2DM; ≥18 years of age; adequate circulation to the affected extremity; DFU: UT grade 1 or 2; 1-25 cm2 in size, absence of infection Received a single application of the GJ-ADM ST: Moist-wound therapy (alginates, foams, hydrogels or hydrocolloids) Debridement, dressing, offloading, systemic antibiotic treatment Proportion of ulcers that completely healed at 12 weeks 12 Driver et al. [24 ] T1/T2DM; ≥18 years of age; HbA1c<12%; adequate vascular perfusion; DFU: Neuropathic, Wagner grade 1 or 2, 1 cm2 ≤ area ≤ 12 cm2 , depth ≤ 5 mm, distal to the malleolus, present for ≥30 days Received single or multiple applications of IFRT ST: Moist wound therapy (sodium chloride gel, nonadherent foam dressing, outer gauze wrap) Debridement, dressing, offloading Percentage of subjects with complete closure of ulcer as assessed by the investigator 16 Cazzell et al. [25 ] T1/T2DM; ≥18 years of age; HbA1c ≤ 12%; adequate arterial blood flow; DFU: Neuropathic, Wagner grade 1-2, 0.5 cm2 to 10 cm2 in size, plantar surface of the foot, a duration ≥6 weeks but<12 months; absence of infection Received weekly applications of OASIS® ultra tri-layer matrix ST: Dressing, debridement Offloading The proportion of 16 Cazzell et al. [26 ] 21-80 years of age; adequate circulation to the affected area; DFU: Wagner grades 1-2, Received one or two applications of D-ADM or GJ-ADM ST: moist wound treatment (alginate, foam, or hydrogel dressings) Debridement, offloading, dressing The proportion of chronic DFUs completely closed at the end of 12 weeks 24 Campitiello et al. [27 ] Diabetes; >18 years of age; Treated with IFWN ST: wet dressing Offloading, antibiotics, compression therapy Percentage of patients with complete closure 6 Zelen et al. [28 ] T1/T2DM; ≥18 years of age; 2 in size, on the foot, present for ≥4 weeks, absence of infection Received weekly applications of HR-ADM ST Dressing, debridement, offloading, systemic antibiotics The difference between the 2 groups in the proportion of ulcers healed at 6 weeks 12 Tchanque-Fossuo et al. [29 ] T1/T2DM; 18-85 years of age; Treated with oasis matrix ST Nonadherent gauze dressing, Iodosorb gel, offloading The percentage of patients who achieved complete ulcer closure by 12 weeks of treatment 28
