Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia

Figure 1

The outline of animal grouping and experimental designs. (a) According to the model to be established and the interventions to be taken, tree shrews were randomly assigned into 5 groups with initial 18 animals in each group, as follows: (a) normal control group (control); (b) sham operation group (sham); (c) diabetes mellitus group (DM); (d) diabetes mellitus+cerebral ischemia group (DM+IS); (e) diabetes mellitus+cerebral ischemia+ischemic conditioning group (DM+IS+PC). Tree shrews in the normal control and sham operation groups were fed with basic chow, and tree shrews in the other 3 groups were fed a high-fat diet for 8 weeks. (b) A schematic diagram shows the timeline and treatments. Detailed experimental procedures are described in the Materials and Methods section.

(a)

(b)