The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

Table 11

Adverse events related to the intervention.

Ref	Type of growth factor	Drug-related main adverse effects
		Pain	Erythema and edema	Cellulitis	Infection	Others
[8–14, 48]	PDGF	N	N	N	N
[21–24]	FGF	N	N	N	N
[16–20]	EGF	N	N	N	N	Dizziness, shivering, and chills appeared more frequently in the EGF-treated groups, apparently dose-dependent
[25–28]	G-CSF	N	N	N	N	Worsened liver function, skin efflorescence
[29]	VEGF	N	N	N	N
[30]	Erythropoietin, epoetin beta	N	N	N	N
[31]	Talactoferrin	N	N	N	N
[32]	Chrysalin®	N	N	N	N
[33]	TGF-β	N	N	N	N

PDGF: platelet-derived growth factor; G-CSF: granulocyte colony-stimulating factor; VEGF: vascular endothelial growth factor; TGF-β: transforming growth factor β; N: no drug-related side effect.