G-CSF therapy was associated with earlier eradication of pathogens from the infected (), quicker resolution of cellulitis (), shorter hospital stays (), and a shorter duration of intravenous antibiotic (). Neutrophil superoxide production was higher in the G-CSF-treated group ()
No foot ulcer had completely healed at the end of the study. Patients who received G-CSF did not have an earlier resolution of clinically defined cellulitis (). The ulcer volume, was reduced by 59% in G-CSF and by 35% in placebo patients ()
No significant differences for duration of hospitalization, duration of parenteral antibiotic administration, time to resolution of infection, and need for amputation
NM
NM
NM
NM
NM
NM
NM
NM
13.3% in the treatment group and 20% in the placebo group.