Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus

Table 2

Demographics and clinical characteristics by DSPN stage^a.

Variables	No DSPN	Minimal DSPN	Subclinical DSPN	DSPN
				DSPN	Mild DSPN	Moderate DSPN	Severe DSPN
Patient no.	64	19	18	44	18	14	12
Gender (F/M)	34/30	6/13	7/11	7/37	3/15	4/10	0/12
Age (y)
BMI (kg/m^2)
Duration of T2DM (y)
HTN, (%)	4 (6.3)	0 (0.0)	1 (5.6)	2 (4.5)	2 (11.1)	0 (0.0)	0 (0.0)
HbA1C (%)
T-CHOL (mg/dl)
HDL-C (mg/dl)
LDL-C (mg/dl)
TG (mg/dl)
Vit. B12 (pg/ml)
Hom (μmol/l)
eGFR (ml/min/1.73m^2)

Abbreviations: mMNSI: modified Michigan Neuropathy Screening Instrument; DSPN: distal symmetrical polyneuropathy; DPNP: diabetic peripheral neuropathic pain; NCS: nerve conduction studies; DN4: Douleur Neuropathique; F: females; M: males; y: years; BMI: body mass index; T2DM: type II diabetes mellitus; HTN: hypertension; HbA1C: glycated haemoglobin; Vit. B₁₂: vitamin B₁₂; HTN: hypertension; Hom: homocysteine; T-CHOL: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; eGFR: estimated glomerular filtration rate. ^a No DSPN, patients with mMNSI total and NCS severity score 0-1; minimal DSPN, patients with mMNSI total and NCS severity score 0-1; subclinical DSPN, patients with mMNSI total and NCS severity ; DSPN, patients with mMNSI total and NCS severity . Data were presented as of F/M for gender, (%) for categorical variables, and for continuous values given DSPN stage. Data were compared with DSPN stage, no DSPN using the chi-squared test for categorical variables and the two-sample -test for continuous ones. , , and indicate significant difference as compared with no DSPN. Data were also compared among DSPN severity (mild, moderate, and severe DSPN) via the one-way ANOVA test for continuous variables and the chi-squared test for categorical variables; and no significance was derived among DSPN severity.